Diseases and the Endocannabinoid System

Diseases

Other Disorders & Therapeutic Uses

Acid reflux Receptors: CB1, CB2 Phytocannabinoids: THC	Klinefelter Syndrome	MDMA intoxication Receptors: CB1, CB2 Phytocannabinoids: THC	Morphine interaction Phytocannabinoids: CBD, THC
Acute liver failure Receptors: CB1, CB2, 5-HT1A, TRPV1 Phytocannabinoids: THC, CBD

Brain Disorders

Addiction Enzymes: MAGL, DAGL Receptors: CB1, CB2, μ-opioid receptor Phytocannabinoids: CBD, THC	Epilepsy Enzymes: MAGL, DAGL, FAAH Receptors: CB1, CB2, TRPV1, GlyR, BK, GPR55 Phytocannabinoids: 11-OH-Δ9-THC, CBD, THC, THCA, THCV, CBN, CBDV, Δ8THC	Migraine Receptors: CB1, CB2, TRPV1 Phytocannabinoids: THC	PTSD Enzymes: FAAH Receptors: CB1, 5-HT1A, PPARα Phytocannabinoids: CBD, THC
ADHD Receptors: CB1 Phytocannabinoids: THC, CBD	Glaucoma Enzymes: MAGL Receptors: CB1, GPR18, GPR119 Phytocannabinoids: THC, Δ8THC, 11-OH-Δ9-THC, CBG, CBN	OCD Receptors: CB1, TRPV1 Phytocannabinoids: CBD	Tinnitus Receptors: CB1 Phytocannabinoids: CBD, THC
ALS Enzymes: MAGL Receptors: CB2, PPARγ Phytocannabinoids: THC, CBG, CBD	Insomnia Receptors: CB1, TRPV1 Phytocannabinoids: CBD, THC	Psychosis and Schizophrenia Enzymes: DAGL, MAGL, FAAH Receptors: 5-HT1A, CB1, PPARγ Phytocannabinoids: CBD, THC, THCV	Tourette's Phytocannabinoids: THC
Anxiety Enzymes: MAGL, DAGL, FAAH Receptors: 5-HT1A, GPR55, CB1, CB2, A2A (Adenosine), PPARγ Phytocannabinoids: CBD, THC

Immune Disorders

AIDS Receptors: CB2 Phytocannabinoids: THC	Crohn's Disease Receptors: CB1, CB2, PPARγ, TRPV1 Phytocannabinoids: THC, THCV, CBD, CBG	Eczema Receptors: CB1, CB2, PPARα, TRPV1 Phytocannabinoids: CBD, THC, THCV, Δ8THC, CBCV	Malaria Receptors: CB2 Phytocannabinoids: CBD, THC
Arthritis Receptors: CB2 Phytocannabinoids: CBD, THC	Cystitis Enzymes: FAAH Receptors: CB1, CB2, PPARα, TRPV1 Phytocannabinoids: CBG	Inflammation Enzymes: MAGL, DAGL, FAAH Receptors: CB1, CB2, GPR55, TRPV1, TRPA1, PPARγ Phytocannabinoids: THC, CBD, THCV	Psoriasis Receptors: CB1, CB2, GPR55, PPARγ, TRPV1 Phytocannabinoids: CBD, CBG, CBN, THC
COPD Receptors: CB1, CB2 Phytocannabinoids: CBD, THC, THCV

Degenerative Disorders
Brain Disorders
Immune Disorders

Alzheimer's disease

Enzymes: MAGL, DAGL, FAAH

Receptors: CB1, CB2, PPARα, PPARγ, GPR3, TRPV1, GPR12

Phytocannabinoids: CBD, THC

Huntington's

Receptors: CB1, CB2, PPARα

Phytocannabinoids: CBG, THC, CBD

Parkinson's

Receptors: CB1, CB2, PPARα, PPARγ, TRPV1, GPR6, GPR12

Phytocannabinoids: CBD, THC, THCA, THCV

Metabolic Disorders
Brain Disorders

Anorexia

Enzymes: FAAH

Receptors: CB1

Phytocannabinoids: THC, CBG

Bulimia

Enzymes: FAAH

Receptors: CB1, GPR119, TRPV1, PPARα

Brain Disorders
Immune Disorders

Autism

Enzymes: FAAH

Receptors: CB1, CB2, GPR55, PPARα, PPARγ

Phytocannabinoids: THC

Depression

Receptors: 5-HT1A, CB1, α2r

Phytocannabinoids: CBC, CBD, CBG, THC

Hypoxic-ischemic encephalopathy

Receptors: 5-HT1A, CB1, CB2, PPARγ, A2A (Adenosine)

Phytocannabinoids: CBD

Stroke

Receptors: 5-HT1A, CB1, CB2, PPARα

Phytocannabinoids: CBD, THC

Cancer

Bladder cancer Receptors: CB1, CB2, GPR55	Cancer Phytocannabinoids: THC, CBD	Leukemia Receptors: CB1, CB2 Phytocannabinoids: CBD, THC	Prostate Cancer Receptors: CB1, CB2, GPR55, PPARγ, TRPV1 Phytocannabinoids: CBD, THC
Bone cancer Receptors: CB1, CB2, TRPV1 Phytocannabinoids: THC	Cervical cancer Receptors: CB1, CB2, TRPV1 Phytocannabinoids: THC	Lung cancer Receptors: TRPV1, PPARγ Phytocannabinoids: THC, CBD	Thyroid cancer Receptors: CB1, CB2 Phytocannabinoids: CBD, CBC, CBG, CBDA, THCA, THC
Breast cancer Receptors: CB1, CB2 Phytocannabinoids: CBD, THC	Glioblastoma Receptors: CB1, CB2, GPR55, TRPV1, TRPV2 Phytocannabinoids: CBD, THC	Pancreatic Cancer Enzymes: FAAH, MAGL Receptors: CB1, CB2 Phytocannabinoids: THC

COVID-19

Receptors: CB1, CB2, PPARγ

Phytocannabinoids: THC, CBD

Gastric cancer

Receptors: PPARα, CB1, GPR119, GPR55, TRPV1, GPR12

Phytocannabinoids: THC

Metabolic Disorders
Immune Disorders

Diabetes

Enzymes: DAGL

Receptors: CB1, CB2, GPR55

Phytocannabinoids: CBD, THC

Obesity

Enzymes: DAGL

Receptors: CB1, GPR119, TRPV1, PPARα

Phytocannabinoids: CBD, THCV

Brain Disorders
Other Disorders & Therapeutic Uses

Fibromyalgia

Phytocannabinoids: THC

Immune Disorders
Metabolic Disorders

Functional Gastro-Intestinal Disorders

Enzymes: FAAH, DAGL

Receptors: CB1, CB2, GPR55, TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, TRPM8, PPARγ

Phytocannabinoids: CBD, THC, CBG, THCV

Immune Disorders
Brain Disorders

Multiple Sclerosis

Receptors: CB1, CB2, PPARγ

Phytocannabinoids: CBD, THC

Other Disorders & Therapeutic Uses
Brain Disorders

Pain

Enzymes: FAAH, MAGL, DAGL

Receptors: CB1, CB2, GPR55, PPARα, TRPA1, TRPM8, TRPV1, TRPV2, TRPV3, TRPV4, α2r, GlyR

Phytocannabinoids: CBD, CBG, THC

Endocannabinoid System

Plant Cannabinoids

10-α-OH-HexaHC Receptors: CB1, CB2	8α-OH-Δ9-THC Receptors: CB1, CB2	CBDA	CMB Receptors: PPARγ
10-α-OH-THC	9β,10β-epoxyhexahydrocannabinol Receptors: CB1, CB2	CBDB	Olivetolic acid
10-α-OH-Δ8THC Receptors: CB1, CB2	Cannabichromanone B	CBDP	THC Receptors: CB1, CB2, GlyR, GPR18, GPR55, TRPA1, TRPM8, TRPV2, TRPV3, TRPV4, 5-HT3A, PPARγ Diseases: Cancer, Multiple Sclerosis, Parkinson's, Alzheimer's disease, Addiction, AIDS, Anorexia, Arthritis, Autism, Cervical cancer, COPD, Fibromyalgia, Functional Gastro-Intestinal Disorders, Depression, Diabetes, Eczema, Epilepsy, Glioblastoma, Insomnia, Leukemia, Lung cancer, MDMA intoxication, Migraine, Morphine interaction, Multiple Sclerosis, Pain, Pancreatic Cancer, Psoriasis, Psychosis and Schizophrenia, PTSD, Stroke, Tourette's
10β-OH-Δ8-THC Receptors: CB1, CB2	Cannabichromanone C	CBDV Receptors: CB1, CB2, TRPV1, TRPV2, TRPA1, GPR55 Diseases: Cancer, Epilepsy	THCA Diseases: Epilepsy
11-acetoxy-Δ9-tetrahydrocannabinolic acid A Receptors: CB1, CB2	Cannabichromanone D	CBG Receptors: 5-HT1A, CB1, CB2, Nav1.1, Nav1.2, Nav1.5, TRPA1, TRPM8, TRPV1, TRPV2, TRPV3, TRPV4, GPR55, α2r, PPARγ Diseases: Anorexia, Cancer, Cystitis, Depression, Diabetes, Functional Gastro-Intestinal Disorders, Huntington's, Pain, Psoriasis, Leukemia, Parkinson's, ALS, Hypoxic-ischemic encephalopathy, Multiple Sclerosis	THCB Receptors: CB1, CB2
4-OH-5-acetoxy-CBG	Cannabiripsol Receptors: CB1, CB2	CBGA	THCP Receptors: CB1, CB2
5-metoxy-CBG	CBC Receptors: TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, TRPM8 Diseases: Functional Gastro-Intestinal Disorders, Depression, Pain	CBGV	THCV Receptors: TRPV1, TRPV2, TRPV3, TRPV4, CB1, CB2, 5-HT1A, GPR55, TRPM8 Diseases: Anxiety, COPD, Diabetes, Eczema, Epilepsy, Functional Gastro-Intestinal Disorders, Obesity, Pain, Parkinson's, Psychosis and Schizophrenia
6,7-epoxy-CBG	CBCV Diseases: Eczema	CBN Receptors: CB1, CB2, TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, TRPM8 Diseases: Anorexia, Cancer, Epilepsy, Hypoxic-ischemic encephalopathy, Pain, Psoriasis	THCVA
8-OH-CBN	CBD Receptors: CB1, CB2, PPARγ, GPR55, GPR18, GPR6, GPR3, TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, TRPM8, Cav3.1, Cav3.2, Cav3.3, 5-HT1A, 5-HT2A, 5-HT3A, Nav1.1, Nav1.2, Nav1.5 Diseases: Addiction, Alzheimer's disease, Anxiety, Arthritis, Cancer, COPD, Depression, Diabetes, Eczema, Epilepsy, Functional Gastro-Intestinal Disorders, Glioblastoma, Hypoxic-ischemic encephalopathy, Insomnia, Leukemia, Lung cancer, Malaria, Morphine interaction, Multiple Sclerosis, Obesity, OCD, Pain, Psoriasis, Psychosis and Schizophrenia, Parkinson's, PTSD, Stroke	CBV	Δ8THC Receptors: CB1, CB2 Diseases: Eczema, Epilepsy

Metabolites

11-COOH-Δ9-THC

11-OH-Δ9-THC

Diseases:

Epilepsy

Endocannabinoids

2AG Enzymes: DAGL, MAGL, FAAH Receptors: CB1, CB2, TRPV1, GPR55 Diseases: Addiction, Alzheimer's disease, Anorexia, Anxiety, Bladder cancer, Depression, Eczema, Epilepsy, Functional Gastro-Intestinal Disorders, Hypoxic-ischemic encephalopathy, Insomnia, Obesity, Pain, Parkinson's, Psychosis and Schizophrenia, Tinnitus	DHEA Receptors: CB1 Diseases: Obesity	OEA Enzymes: FAAH, NAPE-PLD Receptors: PPARα, GPR55, GPR119, TRPV1 Diseases: Autism, Depression, Functional Gastro-Intestinal Disorders, Hypoxic-ischemic encephalopathy, Insomnia, Obesity, Parkinson's, Fibromyalgia, Stroke	STEARDA Receptors: CB1
2AGE/Noladin Receptors: CB1, CB2, GPR55, PPARα, TRPV1	EPEA Diseases: Obesity	OLDA Receptors: CB1, GPR119, TRPV1	VDHP Receptors: CB1 Diseases: Pain
2OG	Hemopressin Receptors: CB1, TRPV1 Diseases: Bulimia, Multiple Sclerosis, Obesity, Pain	PALDA Receptors: CB1	Virodhamine
Anandamide Enzymes: DAGL Receptors: CB1, CB2, TRPV1, PPARα, PPARγ, GPR55 Diseases: Addiction, Anorexia, Anxiety, Autism, Bone cancer, Cervical cancer, COPD, Functional Gastro-Intestinal Disorders, Cystitis, Depression, Diabetes, Eczema, Epilepsy, Hypoxic-ischemic encephalopathy, Malaria, Migraine, Obesity, OCD, Pain, Parkinson's, Psoriasis, Psychosis and Schizophrenia, PTSD, Stroke	NADA	PEA Receptors: GPR119, GPR55, PPARα, TRPV1 Diseases: Alzheimer's disease, Autism, Cystitis, Eczema, Functional Gastro-Intestinal Disorders, Hypoxic-ischemic encephalopathy, Multiple Sclerosis, Pain, Parkinson's, Stroke

Cannabinoid Receptors

5-HT1A Phytocannabinoids: CBD, THCV, CBG Diseases: Anxiety, Breast cancer, Depression, Hypoxic-ischemic encephalopathy, Psychosis and Schizophrenia, Stroke	Cav3.3 Receptors: NarGly, NADA Phytocannabinoids: THC, CBD	K-ATP	PPARγ Phytocannabinoids: THC, CBD Diseases: Alzheimer's disease, Autism, Functional Gastro-Intestinal Disorders, Hypoxic-ischemic encephalopathy, Lung cancer, Multiple Sclerosis, Parkinson's, Prostate Cancer, Psoriasis, Psychosis and Schizophrenia
5-HT2A Phytocannabinoids: CBD	CB1 Phytocannabinoids: THC, Δ8THC, CBD, CBG, THCV Diseases: Addiction, Anorexia, Anxiety, ADHD, Alzheimer's disease, Autism, Bladder cancer, Bone cancer, Breast cancer, Bulimia, Cervical cancer, COPD, Cystitis, Depression, Diabetes, Eczema, Epilepsy, Functional Gastro-Intestinal Disorders, Glioblastoma, Huntington's, Hypoxic-ischemic encephalopathy, Insomnia, Leukemia, Migraine, Multiple Sclerosis, Obesity, OCD, Pain, Pancreatic Cancer, Parkinson's, Prostate Cancer, Psoriasis, Psychosis and Schizophrenia, PTSD, Stroke, Tinnitus	Kv1.2 Phytocannabinoids: THC	TREK-1
5-HT3 Phytocannabinoids: THC	CB2 Phytocannabinoids: 10-α-OH-HexaHC, 10-α-OH-THC, 10-α-OH-Δ8THC, 4-OH-5-acetoxy-CBG, 5-metoxy-CBG, 6,7-epoxy-CBG, 8-OH-CBN, Cannabichromanone B, Cannabichromanone C, Cannabichromanone D, Cannabiripsol, CBD, CBDV, CBG, CBN, CBV, THC, THCA, THCV, Δ8THC Diseases: Addiction, AIDS, Arthritis, Alzheimer's disease, Autism, Bladder cancer, Bone cancer, Breast cancer, Cervical cancer, COPD, Functional Gastro-Intestinal Disorders, Cystitis, Diabetes, Eczema, Epilepsy, Glioblastoma, Huntington's, Hypoxic-ischemic encephalopathy, Leukemia, Migraine, Multiple Sclerosis, Pain, Parkinson's, Prostate Cancer, Psoriasis, Psychosis and Schizophrenia, Stroke	Kv1.5	TRPA1 Diseases: Functional Gastro-Intestinal Disorders, Pain
5-HT3A Phytocannabinoids: THC, CBD	GlyR Phytocannabinoids: THC Diseases: Epilepsy, Pain	Kv3.1	TRPM8 Diseases: Functional Gastro-Intestinal Disorders, Pain
A2A (Adenosine) Phytocannabinoids: CBD Diseases: Hypoxic-ischemic encephalopathy	GPCR introduction	Kv4.3	TRPV1 Diseases: Bone cancer, Bulimia, Cervical cancer, Functional Gastro-Intestinal Disorders, Cystitis, Eczema, Epilepsy, Glioblastoma, Insomnia, Lung cancer, Migraine, Pain, Parkinson's, Prostate Cancer, Psoriasis
BK	GPR119 Diseases: Bulimia, Obesity	nAChR	TRPV2 Phytocannabinoids: CBD, CBG Diseases: Functional Gastro-Intestinal Disorders, Glioblastoma, Pain
Cav1	GPR12 Phytocannabinoids: CBD Diseases: Alzheimer's disease, Parkinson's, Cancer	Nav1.1 Phytocannabinoids: CBC	TRPV3 Phytocannabinoids: CBD, CBN, CBG, CBC, CBDA, CBDV, CBGA, CBGV, THC, THCA, THCV, THCVA Diseases: Functional Gastro-Intestinal Disorders, Pain
Cav2.1	GPR18 Phytocannabinoids: THC, CBD	Nav1.2 Phytocannabinoids: CBD, CBC	TRPV4 Diseases: Functional Gastro-Intestinal Disorders, Pain
Cav2.2	GPR3 Phytocannabinoids: CBD Diseases: Alzheimer's disease	Nav1.5 Phytocannabinoids: CBD, CBC	α2r Phytocannabinoids: CBG Diseases: Depression, Pain
Cav3.1 Receptors: NarGly, NADA Phytocannabinoids: Anandamide	GPR55 Phytocannabinoids: THC, CBD Diseases: Anxiety, Autism, Bladder cancer, Depression, Diabetes, Functional Gastro-Intestinal Disorders, Glioblastoma, Pain, Prostate Cancer, Psoriasis	NMDAr	δ-opioid receptor Phytocannabinoids: THC
Cav3.2 Receptors: NarGly, NADA Phytocannabinoids: THC, CBD	GPR6 Phytocannabinoids: CBD Diseases: Parkinson's	PPARα Diseases: Alzheimer's disease, Autism, Bulimia, Cystitis, Eczema, Huntington's, Obesity, Pain, Parkinson's, Stroke

8β-OH-Δ9-THC Receptors: CB1, CB2	NarGly	TASK-1	μ-opioid receptor Phytocannabinoids: THC Diseases: Addiction
Cannabinoids Info	RVDHP Receptors: CB1 Diseases: Anxiety, PTSD	TASK-3

Terpenes

Caryophyllene Receptors: CB2, 5-HT1A, PPARα, PPARγ Diseases: Addiction, Pain, Epilepsy, Hypoxic-ischemic encephalopathy, Alzheimer's disease, Parkinson's, Glioblastoma, Anxiety, Cancer	Humulene Diseases: Cancer	Linalool Receptors: TRPA1, 5-HT3, 5-HT1A, μ-opioid receptor, δ-opioid receptor, PPARγ, NMDAr, A2A (Adenosine), TRPM8, nAChR Diseases: Pain, Depression, Addiction, Obesity	Pinene Diseases: Pain
Eugenol Diseases: Breast cancer, Diabetes, Epilepsy, Leukemia, Pain, Obesity	Limonene Receptors: TRPA1, A2A (Adenosine), PPARα Diseases: Lung cancer, Prostate Cancer, Cancer, Pain, Obesity	Myrcene Diseases: Stroke, Functional Gastro-Intestinal Disorders, Pain

Synthesizing & Degrading Enzymes

Cytochrome-p450	FAAH Diseases: Anorexia, Anxiety, Autism, Depression, Functional Gastro-Intestinal Disorders, Pain, Psychosis and Schizophrenia	MAGL Receptors: CB1 Diseases: Addiction, Alzheimer's disease, Anxiety, Cancer, Pain, Psychosis and Schizophrenia	NAPE-PLD
DAGL Receptors: CB1 Diseases: Addiction, Alzheimer's disease, Anxiety, Diabetes, Functional Gastro-Intestinal Disorders, Obesity, Pain, Psychosis and Schizophrenia