Kv1.5

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Introduction

Kv1.5 is a potassium channel that is involved in restoring the resting membrane potential after depolarisation. Kv1.5 is not a classic Cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Kv1.5 it is effectively a Cannabinoid receptor.

Chemical Name

Potassium voltage-gated channel, shaker-related subfamily, member 5, KCNA5

IUPHAR entry

Wikipedia Entry

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Literature Discussion

Anandamide 2AG  

References:

Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.

Distribution Summary

Brain: hippocampus, cortex, pituitary, oligodendrocytes, microglia, Schwann cells. Pulmonary arterial smooth muscle, spinal cord. Skeletal muscle. Atrial myocytes, atrium, ventricle.

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