Kv1.5 is a potassium channel that is involved in restoring the resting membrane potential after depolarisation. Kv1.5 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Kv1.5 it is effectively a cannabinoid receptor.

Chemical Name: 
Potassium voltage-gated channel, shaker-related subfamily, member 5, KCNA5
IUPHAR entry: 
Wikipedia entry: 

Brain: hippocampus, cortex, pituitary, oligodendrocytes, microglia, Schwann cells. Pulmonary arterial smooth muscle, spinal cord. Skeletal muscle. Atrial myocytes, atrium, ventricle.

Literature Discussion: 

Anandamide 2AG  


Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.