CB1

CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways.

2AGE/Noladin

Suspected cannabinoid that binds to several cannabinoid receptors.

2AG

2AG is a major endocannabinoid produced from lipids in cellular membranes, mostly but not exclusively in response to cellular activity.

Anandamide

Anandamide was the first identified endocannabinoid, named after the Sanskrit 'ananda' for inner bliss. Anandamide is produced from lipids in cellular membranes throughout the body.

Tinnitus

Tinnitus is described as a sensation of hearing sounds without any external source. This sensation can be similar to hear ringing, clicking, hissing or other sounds. Tinnitus can interfere with concentration and sleep and can cause Anxiety, depression and suicide attempt.

Parkinson's

Parkinson's Disease is a degenerative disorder of the nervous system marked by accelerated degeneration of dopamine-producing neurons in the Substantia Nigra in the brain.

Typical symptoms of Parkinson's Disease , such as (intentional) tremor, rigidity and slowness of movement are mostly ascribed to degenerating Substantia Nigra neurons.

Obesity

Energy homeostasis (balance)  is one of the primary functions of the endocannabinoid system.

Epilepsy

cannabinoids have excellent therapeutic potential in epilepsy. In the brain, cannabinoids tend to keep neuronal activity wihtin acceptable boundaries. More importantly, cannabinoids prevent hypersynchronisation of cortical neurons (which is the very definition of a seizure).

Eczema

Eczema or dermatitis is a (chronic) inflammation of the skin. Eczema is marked by itchy skin and crusty skin lesions. It is not known what exactly causes eczema but an over-active immune system may at least be part of the cause. Therefore, a faulty endocannabinoid system may cause eczema offering potential for cannabinoid-based therapy.

Depression

Both plant cannabinoids and the endocannabinoid system have been implicated as risk factors in the development of depression as well as therapeutic targets to treat depression.