CB1

CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways. 

2AG

2AG is a major endocannabinoid produced from lipids in cellular membranes, mostly but not exclusively in response to cellular activity.

Anandamide

Anandamide was the first identified endocannabinoid, named after the Sanskrit 'ananda' for inner bliss. Anandamide is produced from lipids in cellular membranes throughout the body.

Addiction

Addiction is a complex physiological phenomenon that is intimately linked to the dopamine neurotransmitter system. Neurons in the dopamine system are studded with cannabinoid receptors (like CB1) which explains the addictive properties of cannabinoid substances. However, the interaction between the cannabinoid system and the dopamine system also offers opportunities for cannabinoids in the treatment of addiction to for instance alcohol, food, nicotine or opioids.

Autism

Autism is a neurodevelopmental disorder characterized by impaired social interaction, verbal and non-verbal communication, and restricted and repetitive behavior.

Bulimia

cannabinoids and endocannabinoids are known to strongly affect eating behavior. THC typically induces hunger and THCV suppresses it.

Cystitis

Cystitis is an infection of the urinary tract.

Depression

Both plant cannabinoids and the endocannabinoid system have been implicated as risk factors in the development of depression as well as therapeutic targets to treat depression.

Diabetes

Diabetes has two major forms: Type 1 Diabetes is an auto-immune disorder where insulin-producing β-cells in the pancreatic Islets of Langerhans are attacked by the body's immune system resulting in reduced insulin production.

Migraine

Migraine is a chronic neurological disorder that is mostly characterized by severe headaches and aura.