Kv1.2

Kv1.2 is a potassium channel that is responsible for maintaining resting membrane potential and regulating excitability in neurons. Kv1.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

K-ATP

K-ATP is a potassium channel that is sensitive to ATP and therefore to cellular energy levels. K-ATP functions to control cellular energy levels.

GPR18

GPR18 is involved in apoptosis, microglial migration in the CNS and other immune responses.

GPR119

GPR119 is involved in insulin secretion and its activation was shown to reduce food intake, suggesting a metabolic function.

GlyR

Glycine receptors are sensitive to glycine and produce a hyperpolarising current upon activation. GlyRs are not classic cannabinoid receptora but their activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on GlyRs they are effectively cannabinoid receptors.

CB2

CB2 is primarily expressed in the immune cells and tissues of the body. Like CB1, CB2 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently lowers cAMP upon activation. This, in turn, regulates many second messenger pathways.

Cav3.2

Cav3.2 is a calcium channel of the T-type that is involved in many processes in the brain and other tissues. Contrary to other calcium channels Cav3.2 is activated by relatively low/negative voltages.

Cav2.2

Cav2.2 is a calcium channel of the N-type that is involved in many basal brain processes including learning and memory. Cav2.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Cav2.1

Cav2.1 is a calcium channel of the P/Q type that is central to many brain processes, including learning and memory. Cav2.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

BK

BK channels are ion channels with a large conductance for potassium ions. BK channels are mostly involved in controlling neuronal excitability and smooth muscle contraction.