Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Kv1.2 is a potassium channel that is responsible for maintaining resting membrane potential and regulating excitability in neurons. Kv1.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
K-ATP is a potassium channel that is sensitive to ATP and therefore to cellular energy levels. K-ATP functions to control cellular energy levels.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
GPR18 is involved in apoptosis, microglial migration in the CNS and other immune responses.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
GPR119 is involved in insulin secretion and its activation was shown to reduce food intake, suggesting a metabolic function.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Glycine receptors are sensitive to Glycine and produce a hyperpolarising current upon activation. GlyRs are not classic cannabinoid receptora but their activity is modulated by cannabinoids.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
CB2 is primarily expressed in the immune cells and tissues of the body. Like CB1, CB2 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently lowers cAMP upon activation. This, in turn, regulates many second messenger pathways.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Cav3.2 is a calcium channel of the T-type that is involved in many processes in the brain and other tissues. Contrary to other calcium channels Cav3.2 is activated by relatively low/negative voltages.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Cav2.2 is a calcium channel of the N-type that is involved in many basal brain processes including learning and memory. Cav2.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Cav2.2 it is effectively a cannabinoid receptor.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Cav2.1 is a calcium channel of the P/Q type that is central to many brain processes, including learning and memory. Cav2.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
BK channels are ion channels with a large conductance for potassium ions. BK channels are mostly involved in controlling neuronal excitability and smooth muscle contraction.