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Glycine receptors are sensitive to Glycine and produce a hyperpolarising current upon activation. GlyRs are not classic cannabinoid receptora but their activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on GlyRs they are effectively cannabinoid receptors.

Chemical Name

Glycine receptor

IUPHAR entry

Wikipedia Entry



Literature Discussion

Anandamide Δ9THC  


Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.  

Distribution Summary

GlyRs ar widely distributed throughout the central nervous system with particularly high expression in the spinal cord and brain stem.

Distribution from Human Protein Atlas: 
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