Epilepsy

cannabinoids have excellent therapeutic potential in epilepsy. In the brain, cannabinoids tend to keep neuronal activity wihtin acceptable boundaries. More importantly, cannabinoids prevent hypersynchronisation of cortical neurons (which is the very definition of a seizure).

Eczema

Eczema or dermatitis is a (chronic) inflammation of the skin. Eczema is marked by itchy skin and crusty skin lesions. It is not known what exactly causes eczema but an over-active immune system may at least be part of the cause. Therefore, a faulty endocannabinoid system may cause eczema offering potential for cannabinoid-based therapy.

Depression

Both plant cannabinoids and the endocannabinoid system have been implicated as risk factors in the development of depression as well as therapeutic targets to treat depression.

Kv4.3

Kv4.3 is a potassium channel that is involved in the repolarisation of action potentials in cardiac muscle. Kv4.3 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv3.1

Kv3.1 is a potassium channel that functions in action potential repolarisation in fast-firing neurons. Kv3.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv1.2

Kv1.2 is a potassium channel that is responsible for maintaining resting membrane potential and regulating excitability in neurons. Kv1.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

GlyR

Glycine receptors are sensitive to Glycine and produce a hyperpolarising current upon activation. GlyRs are not classic cannabinoid receptora but their activity is modulated by cannabinoids.

5-HT3

5-HT3 is a serotonin receptor. 5-HT3 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on 5-HT3 it is effectively a cannabinoid receptor.

δ-opioid receptor

δ-opioid receptors are primarily sensitive to opioids and enkephalins. δ-opioid receptors are not classic cannabinoid receptors but their activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on δ-opioid receptors they are effectively cannabinoid receptors.

Cav3.3

Cav3.3 is a calcium channel of the T-type that is involved in many brain processes. Contrary to other calcium channels Cav3.3 is activated by relatively low/negative voltages.