Kv1.2 is a potassium channel that is responsible for maintaining resting membrane potential and regulating excitability in neurons. Kv1.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Kv1.2 it is effectively a cannabinoid receptor.

Chemical Name: 
Potassium voltage-gated channel subfamily A member 2, KCNA2
IUPHAR entry: 
Wikipedia entry: 
Distribution: 

Brain (pons, medulla, cerebellum, inferior colliculus > hippocampus, thalamus, cerebral cortex, superior colliculus > midbrain, corpus striatum, olfactory bulb)(neurons associated with mechanoreception and proprioception) Skeletal and cardiac muscles Retina Spinal cord Sciatic nerve

Endocannabinoids: 
Phytocannabinoids: 
Literature Discussion: 

Anandamide Δ9THC  

References:

Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.

Tags: 

Anandamide

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