δ-opioid receptor

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Introduction

δ-opioid receptors are primarily sensitive to opioids and enkephalins. δ-opioid receptors are not classic Cannabinoid receptors but their activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on δ-opioid receptors they are effectively Cannabinoid receptors.

Chemical Name

δ-opioid receptor

IUPHAR entry

Wikipedia Entry

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Literature Discussion

Δ9THC  

References:

Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.

Distribution Summary

δ-opioid receptors are widely distributed throughout the CNS, most prominant expression in the forebrain regions: Caudate putamen, nucleus accumbens, amygdala, pontine nucleus, olfactory bulb, olfactory tubercle > interpeduncular nucleus, cortex (most dense in layers II-III and V-VI) > thalamus, hypothalamus, stria terminalis, hippocampus, globus pallidus, preoptic area, colliculi. Virtually no binding in the periaqueductal grey and raphe nuclei.

Distribution from Human Protein Atlas: 
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