PTSD

Posttraumatic stress disorder is considered a mental disorder caused after traumatic experiences like traffic accidents, violent circumstances, rape, warfare, etc. Typical symptoms include anxiety, nightmares, flashbacks and trauma-related cues.

Epilepsy

cannabinoids have excellent therapeutic potential for the treatment of epilepsy. In the brain, the endocannabinoid system tends to keep neuronal activity wihtin acceptable boundaries.

Psychosis and Schizophrenia

Schizophrenia is a chronic mental disorder that affects around 1% of the worldwide population. It causes psychotic behaviors, social and emotional disruptions and different cognitive impairments.

The causes of the disease are still not clear but studies show that both genetic and environmental factors have an effect on it.

Pain

pain is a very good target for therapeutic cannabinoids.

TRPV1

TRPV1 is part of the transient receptor potential family and is one of the non-GPCR cannabinoid receptors. TRPV1 is involved in thermoregulation and pain detection (nociception).

TREK-1

TREK-1 is a postassium channel that is constitutively leaky, thereby maintaining resting membrane potential. Mechanical membrane stretching and certain anaesthetics can open the channel, thus greatly reducing neuronal excitability.

NMDAr

NMDA receptors are sensitive to the neurotransmitter glutamate. NMDArs are best known for their function in neurons as coincidence detectors and consequently their role in learning and memory. NMDArs are not classic cannabinoid receptors but their activity is modulated by cannabinoids.

Kv4.3

Kv4.3 is a potassium channel that is involved in the repolarisation of action potentials in cardiac muscle. Kv4.3 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv3.1

Kv3.1 is a potassium channel that functions in action potential repolarisation in fast-firing neurons. Kv3.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv1.5

Kv1.5 is a potassium channel that is involved in restoring the resting membrane potential after depolarisation. Kv1.5 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.