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Cav3.2 is a calcium channel of the T-type that is involved in many processes in the brain and other tissues. Contrary to other calcium channels Cav3.2 is activated by relatively low/negative voltages. Cav3.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Cav3.2 it is effectively a cannabinoid receptor.

Chemical Name

Calcium channel, voltage-dependent, T type, alpha 1H subunit

IUPHAR entry

Wikipedia Entry



Literature Discussion

NarGly NADA Anandamide 2AG CBD Δ9THC


Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.

Distribution Summary

Kidney > liver > heart, brain.> lung, skeletal muscle, pancreas, placenta. Putamen > amygdala, caudate nucleus > frontal lobe, hippocampus, cerebellum, substantia nigra > thalamus > medulla, spinal cord, occipital lobe, temporal lobe.  

Distribution from Human Protein Atlas: 
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