CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways. 

TRPV1 is part of the transient receptor potential family and is one of the non-GPCR cannabinoid receptors. TRPV1 is involved in thermoregulation and pain detection (nociception).

pparγ is part of the nuclear receptor family and one of the non-GPCR cannabinoid receptors. pparγ is involved in the regulation of fat cells/adipose tissue, insulin sensitivity and inflammation.

Kv4.3 is a potassium channel that is involved in the repolarisation of action potentials in cardiac muscle. Kv4.3 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv3.1 is a potassium channel that functions in action potential repolarisation in fast-firing neurons. Kv3.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

CB2 is primarily expressed in the immune cells and tissues of the body. Like CB1, CB2 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently lowers cAMP upon activation. This, in turn, regulates many second messenger pathways.

Cav3.2 is a calcium channel of the T-type that is involved in many processes in the brain and other tissues. Contrary to other calcium channels Cav3.2 is activated by relatively low/negative voltages.

Cav3.1 is a calcium channel of the T-type that is involved in many processes in the brain and other tissues. Contrary to other calcium channels Cav3.1 is activated by relatively low/negative voltages. Cav3.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Cav3.1 it is effectively a cannabinoid receptor.

Cav3.3 is a calcium channel of the T-type that is involved in many brain processes. Contrary to other calcium channels Cav3.3 is activated by relatively low/negative voltages.

PALDA is an endocannabinoid with weak CB1 affinity.