Left Top


Cav3.3 is a calcium channel of the T-type that is involved in many brain processes. Contrary to other calcium channels Cav3.3 is activated by relatively low/negative voltages. Cav3.3 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Cav3.3 it is effectively a cannabinoid receptor.

Chemical Name

Calcium channel, voltage-dependent, T type, alpha 1I subunit

IUPHAR entry

Wikipedia Entry



Literature Discussion

NarGly NADA Anandamide CBD Δ9THC


Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.

Distribution Summary

Brain (cerebellum, occipital lobe, frontal lobe, amygdale, caudate nucleus, hippocampus > temporal lobe, putamen > substantia nigra, medulla). Isocortex, olfactory > striatum > cortical subplate, hippocampus > thalamus, hypothalamus, pallidum, midbrain, medulla. Soma and entire dendrite in cortical CA3, hippocampal and subicular neurons.

Distribution from Human Protein Atlas: 
PDF Download: