CBD

CBD is the second most common cannabinoid from the plant of cannabis.

CB1

CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways. 

CBDV

CBDV is a non-psychoactive cannabinoid with anti-convulsant properties like its homolog CBD. It has also other potential therapeutic properties as antitumorigenic, anti-acne and antiemetic effects.

Insomnia

Insomnia is a sleep disorder characterized by inability to sleep or sleeping less time than desired. The endocannabinoid system plays a role in sleep processes and medical cannabis users already reported benefits of cannabis use to sleep. More research on the molecular mechanism of cannabinoids in sleep processes could uncover their potential on treating sleep disorders.

Depression

Both plant cannabinoids and the endocannabinoid system have been implicated as risk factors in the development of depression as well as therapeutic targets to treat depression.

Diabetes

Diabetes has two major forms: Type 1 Diabetes is an auto-immune disorder where insulin-producing β-cells in the pancreatic Islets of Langerhans are attacked by the body's immune system resulting in reduced insulin production.

Eczema

Eczema or dermatitis is a (chronic) inflammation of the skin. Eczema is marked by itchy skin and crusty skin lesions. It is not known what exactly causes Eczema but an over-active immune system may at least be part of the cause.

Hypoxic-ischemic encephalopathy

Hypoxic-ischemic encephalopathy is a form of brain injury caused by oxygen deprivation during the birth process. It can cause sensorimotor and cognitive impairments including physical and intellectual disability.

Morphine interaction

Morphine is an opioid drug used to treat acute and chronic pain.

Malaria

Malaria is an infectious disease caused by Plasmodia parasitic protozoa. This disease is transmitted by a mosquito bite with a large variety of symptoms like fever, headache and seizures. It can cause neurological problems and death. For those people who survive Malaria infection, the chances to have neurological complications and cognitive impairments are high.