pain is a very good target for therapeutic cannabinoids.


TREK-1 is a postassium channel that is constitutively leaky, thereby maintaining resting membrane potential. Mechanical membrane stretching and certain anaesthetics can open the channel, thus greatly reducing neuronal excitability.


Cav3.2 is a calcium channel of the T-type that is involved in many processes in the brain and other tissues. Contrary to other calcium channels Cav3.2 is activated by relatively low/negative voltages.


5-metoxy-CBG is a recently discovered cannabinoid. The physiological and therapeutic properties of 6,7-epoxy-CBG remain to be investigated.