BK

Left Top

Introduction

BK channels are ion channels with a large conductance for potassium ions. BK channels are mostly involved in controlling neuronal excitability and smooth muscle contraction. BK is not a classic Cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on BK it is effectively a Cannabinoid receptor.

Chemical Name

Big potassium channel, slo1

IUPHAR entry

Wikipedia Entry

Tags

Bottom

Literature Discussion

Anandamide  

References:

Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.

Distribution Summary

BK channels are neuronal and are mostly found in neocortex (layer V/VI), pyriform cortex, septum (bed nucleus of the stria terminalis, lateral septum), thalamus (rhomboid nucleus).

Distribution from Human Protein Atlas: 
PDF Download: