GPR3 is an orphan receptor which has been associated with Alzheimer's disease. CBD acts as inverse agonist of GPR3, suggesting therapeutic potential to treat Alzheimer's disease.

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GPR3 and GPR6 have been previously linked to Alzheimer's and Parkinson's diseases. These receptors share about 35% of amino acid sequence with CB1 and CB2. CBD acts as an inverse agonist for these receptors as it has been shown in a β-arrestin2 recruitment assay (Laun & Song, 2017).


Laun, A. S., & Song, Z.-H. (2017). GPR3 and GPR6, novel molecular targets for cannabidiol. Biochemical and Biophysical Research Communications, 490(1), 17-21.