Cav1

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Introduction

Cav1 is a family of calcium channels of the L-type that are involved in many basic signalling processes in brain and muscle. Cav1's are not classic Cannabinoid receptors but their activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Cav1's they are effectively Cannabinoid receptors.

Chemical Name

Cav1.x, L type calcium channel

IUPHAR entry

Wikipedia Entry

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Literature Discussion

2AG  

References:

Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.

Distribution Summary

Basal ganglia (caudate nucleus, pallidum > putamen), cerebral cortex, hippocampus, substantia nigra, spinal cord. Cerebrum, cerebellum, spinal cord, dorsal root ganglia, lung, small intestine, testis. Skeletal muscle (predominantly transverse tubules) > bone marrow.

Distribution from Human Protein Atlas: 
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