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GPR12 is an orphan receptor which has been associated with cancer metastasis, Alzheimers and Parkinson's disease. CBD acts as inverse agonist of GPR12, suggesting therapeutic potential to treat any of the mentioned diseases.



Literature Discussion

GPR12 is an orphan receptor which has been proposed as a cannabinoid receptor. This receptor has been linked to Parkinson’s and Alzheimer’s disease (Morales, Isawi, & Reggio, 2018; Morales & Reggio, 2017)

GPR12 has been linked to cell proliferation and survival (Lu, Zhang, Meng, Dong, & Hu, 2012)

CBD acts as an inverse agonist of GPR12 and could have the potential to block cancer metastasis (Brown, Laun, & Song, 2017)


Brown, K. J., Laun, A. S., & Song, Z.-H. (2017). Cannabidiol, a novel inverse agonist for GPR12. Biochemical and Biophysical Research Communications493(1), 451-454.

Lu, X., Zhang, N., Meng, B., Dong, S., & Hu, Y. (2012). Involvement of GPR12 in the regulation of cell proliferation and survival. Molecular and Cellular Biochemistry366(1-2), 101-110.

Morales, P., Isawi, I., & Reggio, P. H. (2018). Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12. Drug Metabolism Reviews50(1), 74-93.

Morales, P., & Reggio, P. H. (2017). An Update on Non-CB1, Non-CB2cannabinoid Related G-Protein-Coupled Receptors. Cannabis and cannabinoid Research2(1), 265-273.

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