GPR12 is an orphan receptor which has been proposed as a cannabinoid receptor. This receptor has been linked to Parkinson’s and Alzheimer’s disease (Morales, Isawi, & Reggio, 2018; Morales & Reggio, 2017)

GPR12 has been linked to cell proliferation and survival (Lu, Zhang, Meng, Dong, & Hu, 2012)

CBD acts as an inverse agonist of GPR12 and could have the potential to block cancer metastasis (Brown, Laun, & Song, 2017)

Literature:

Brown, K. J., Laun, A. S., & Song, Z.-H. (2017). Cannabidiol, a novel inverse agonist for GPR12. Biochemical and Biophysical Research Communications, 493(1), 451-454. https://doi.org/10.1016/j.bbrc.2017.09.001

Lu, X., Zhang, N., Meng, B., Dong, S., & Hu, Y. (2012). Involvement of GPR12 in the regulation of cell proliferation and survival. Molecular and Cellular Biochemistry, 366(1-2), 101-110. https://doi.org/10.1007/s11010-012-1287-x

Morales, P., Isawi, I., & Reggio, P. H. (2018). Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12. Drug Metabolism Reviews, 50(1), 74-93. https://doi.org/10.1080/03602532.2018.1428616

Morales, P., & Reggio, P. H. (2017). An Update on Non-CB1, Non-CB2cannabinoid Related G-Protein-Coupled Receptors. Cannabis and cannabinoid Research, 2(1), 265-273. https://doi.org/10.1089/can.2017.0036