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Nav1.1 is a sodium channel that is primarily expressed in the brain and cardiac muscle where it functions in action potential generation and propagation. Nav1.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Nav1.1 it is effectively a cannabinoid receptor.

Chemical Name

sodium channel, voltage-gated, type I, alpha subunit (SCN1A)

IUPHAR entry

Wikipedia Entry


Literature Discussion

CBD and CBG block NAV 1.1 (Hill et al., 2014).


Hill, A.J., Jones, N.A., Smith, I., Hill, C.L., Williams, C.M., Stephens, G.J., and Whalley, B.J. (2014). Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se. Neurosci. Lett. 566, 269–274.

Distribution Summary

Nav1.1 is present in: Brain neurons, primarily cell bodies and axon initial segments. Cardiac myocytes (sino-atrial node, atrial myocytes and transverse tubules of ventricular myocytes).

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