Nav1.1 is a sodium channel that is primarily expressed in the brain and cardiac muscle where it functions in action potential generation and propagation. Nav1.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Nav1.1 it is effectively a cannabinoid receptor.
Nav1.1 is present in: Brain neurons, primarily cell bodies and axon initial segments. Cardiac myocytes (sino-atrial node, atrial myocytes and transverse tubules of ventricular myocytes).