Nav1.1 is a sodium channel that is primarily expressed in the brain and cardiac muscle where it functions in action potential generation and propagation. Nav1.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Nav1.1 it is effectively a cannabinoid receptor.
CBD and CBG block NAV 1.1 (Hill et al., 2014).
Hill, A.J., Jones, N.A., Smith, I., Hill, C.L., Williams, C.M., Stephens, G.J., and Whalley, B.J. (2014). Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se. Neurosci. Lett. 566, 269–274.
Nav1.1 is present in: Brain neurons, primarily cell bodies and axon initial segments. Cardiac myocytes (sino-atrial node, atrial myocytes and transverse tubules of ventricular myocytes).
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