2OG

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Introduction

Suspected endocannabinoid. Does not bind classical endocannabinoid receptors (CB1/2) but targets GPR119.  

Chemical Name

2-oleoyl glycerol

IUPHAR entry

Wikipedia Entry

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Synthetic Pathways

PLCβ: Phospholipase C β

Produces Diacylglycerol (DAG) from phospholipids

DAGLα: Diacylglycerol Lipase α

Produces 2AG from DAG

DAGLβ: Diacylglycerol Lipase β

Produces 2AG from DAG (probably not involved in depolarisation-induced suppression of excitation/inhibition (DSE/DSI))

  Literature: Endocannabinoids, Related Compounds and Their Metabolic Routes. Fezza F, Bari M, Florio R, Talamonti E, Feole M, Maccarrone M. Molecules. 2014 Oct 24;19(11):17078-17106. Review. PMID: 25347455 Free Article

Degradation Pathways

MAGL: Monoacylglycerol Lipase

Serine hydrolase cleaving 2AG into arachidonic acid (AA) and glycerol

FAAH1: Fatty Acid Amide Hydrolase

Serine Hydrolase, probably more involved in Anandamide degradation

  Literature: Endocannabinoids, Related Compounds and Their Metabolic Routes. Fezza F, Bari M, Florio R, Talamonti E, Feole M, Maccarrone M. Molecules. 2014 Oct 24;19(11):17078-17106. Review. PMID: 25347455 Free Article