EPEA is synthesized from EPA, a major Ω-3 Fatty Acid in the brain.
endocannabinoids are derived from Poly Unsaturated Fatty Acids (PUFAs) with Anandamide and 2AG coming from Ω-6 PUFAs and EPA and DHA coming from Ω-3 PUFAs. The typical Western diet is low on PUFAs and has a low Ω-3/Ω-6 ratio. Shifting the balance to a higher Ω-3 content leads to weight loss, presumably through differential activation of the endocannabinoidsystem (Watkins and Kim, 2014).
Watkins, B.A., and Kim, J. (2014). The endocannabinoid system: directing eating behavior and macronutrient metabolism. Front. Psychol. 5, 1506.
CB1 CB2 PPARγ Literature: Endocannabinoids, Related Compounds and Their Metabolic Routes. Fezza F, Bari M, Florio R, Talamonti E, Feole M, Maccarrone M. Molecules. 2014 Oct 24;19(11):17078-17106. Review. PMID: 25347455 Free Article