CB2 receptors are upregulated in human Bladder Cancer (BC) cells RT4 and RT112. Activation of CB2 with synthetic cannabinoid agonist JWH015 induced cytotoxicity in BC and changes in cellular sphingolipids metabolism (Bettiga et al., 2017).
2AG regulates inflammation and proliferation processes of bladder carcinoma cells, probably through CB receptors (Gasperi et al., 2014).
Bakali, E., Elliott, R.A., Taylor, A.H., Lambert, D.G., Willets, J.M., and Tincello, D.G. (2014).Human urothelial cell lines as potential models for studying cannabinoid and excitatory receptor interactions in the urinary bladder. Naunyn. Schmiedebergs Arch. Pharmacol. 387, 581–589.
Bettiga, A., Aureli, M., Colciago, G., Murdica, V., Moschini, M., Lucianò, R., … Benigni, F. (2017). Bladder Cancer cell growth and motility implicate cannabinoid 2 receptor-mediated modifications of sphingolipids metabolism. Scientific Reports, 7, 42157. https://doi.org/10.1038/srep42157
Gasperi, V., Evangelista, D., Oddi, S., Florenzano, F., Chiurchiù, V., Avigliano, L., Catani, M.V., and Maccarrone, M. (2014). Regulation of inflammation and proliferation of human bladder carcinoma cells by type-1 and type-2 cannabinoid receptors. Life Sci.