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Nicotinic acetylcholine receptors/nAChRs are involved in cognitive processes in the brain and in controlling muscle movement. nAChRs are not classic cannabinoid receptors but their activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on nAChRs they are effectively cannabinoid receptors.

Chemical Name

Nicotinic Acetylcholine receptor

IUPHAR entry

Wikipedia Entry


Literature Discussion

Anandamide 2AG  


Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.

Distribution Summary

nAChRs are expressed in brain and in muscle.