nAChR

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Introduction

Nicotinic acetylcholine receptors/nAChRs are involved in cognitive processes in the brain and in controlling muscle movement. nAChRs are not classic cannabinoid receptors but their activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on nAChRs they are effectively cannabinoid receptors.

Chemical Name

Nicotinic Acetylcholine receptor

IUPHAR entry

Wikipedia Entry

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Literature Discussion

anandamide 2AG  

References:

Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.

Distribution Summary

nAChRs are expressed in brain and in muscle.