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Parkinson's Disease is a degenerative disorder of the nervous system marked by accelerated degeneration of dopamine-producing neurons in the Substantia Nigra in the brain.

Typical symptoms of Parkinson's Disease , such as (intentional) tremor, rigidity and slowness of movement are mostly ascribed to degenerating Substantia Nigra neurons.

As the disease progresses other neurons, such as those in the cerebral cortex also start to degenerate. At this stage, secondary symptoms such as dementia and depression become prominent.

The therapeutic potential of cannabinoids in Parkinson's Disease is probably mostly due to their neuroprotective properties but this still remains to be conclusively shown.

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