CBD

CBD is the second most common cannabinoid from the plant of cannabis. In contrast to THC, CBD is not psychoactive and the reduced side effects associated to its administration makes it as important as THC regarding its therapeutic properties.

CB1

CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways.

CBDV

CBDV is a non-psychoactive cannabinoid with anti-convulsant properties like its homolog CBD. It has also other potential therapeutic properties as antitumorigenic, anti-acne and antiemetic effects.

Stroke

A stroke is marked by reduced blood flow to the brain. This reduction can be due to a blocked blood vessle (ischaemia) or a ruptured blood vessle (aneurism). Either way, as a result (part of) the brain is deprived of oxygen and nutrients which in turn causes neuronal degradation and cognitive decline.

Tinnitus

Tinnitus is described as a sensation of hearing sounds without any external source. This sensation can be similar to hear ringing, clicking, hissing or other sounds.

Parkinson's

Parkinson's Disease is a degenerative disorder of the nervous system marked by accelerated degeneration of dopamine-producing neurons in the Substantia Nigra in the brain.

Typical symptoms of Parkinson's Disease , such as (intentional) tremor, rigidity and slowness of movement are mostly ascribed to degenerating Substantia Nigra neurons.

Pain

pain is a very good target for therapeutic cannabinoids.

TRPV3

TRPV3 is one of the non-GPCR-coupled cannabinoid receptors. TRPs are typically involved in pain sensation.

TRPA1

TRPA1 is best known as a sensor for environmental irritants, pain, cold and stretch.

TRPM8

TRPM8 is involved in sensory perception.