CBD

CBD is the second most common cannabinoid from the plant of cannabis.

CB1

CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways.

CBDV

CBDV is a non-psychoactive cannabinoid with anti-convulsant properties like its homolog CBD. It has also other potential therapeutic properties as antitumorigenic, anti-acne and antiemetic effects.

Psychosis and Schizophrenia

Schizophrenia is a chronic mental disorder that affects around 1% of the worldwide population. It causes psychotic behaviors, social and emotional disruptions and different cognitive impairments.

The causes of the disease are still not clear but studies show that both genetic and environmental factors have an effect on it.

Pain

pain is a very good target for therapeutic cannabinoids.

Obesity

Energy homeostasis (balance)  is one of the primary functions of the endocannabinoid system.

Diabetes

Diabetes has two major forms: Type 1 diabetes is an auto-immune disorder where insulin-producing β-cells in the pancreatic Islets of Langerhans are attacked by the body's immune system resulting in reduced insulin production. Type 2 diabetes results from increased tolerance of cells to insulin resulting in a reduced effect of insulin.

Alzheimer's disease

Alzheimer’s disease is a chronic neurodegenerative disease and the main cause of dementia. Main common symptoms of dementia are related with memory but other cognitive processes are affected during the development of the disease.

Nav1.5

Nav1.5 is a sodium channel that is primarily found in cardiac muscle where it is responsible for action potential generation/cardiac muscle contraction. Nav1.5 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Nav1.2

Nav1.2 is a sodium channel that is involved in action potential generation in neurons and in muscle. Nav1.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.