Diabetes

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Introduction

Diabetes has two major forms: Type 1 Diabetes is an auto-immune disorder where insulin-producing β-cells in the pancreatic Islets of Langerhans are attacked by the body's immune system resulting in reduced insulin production. Type 2 Diabetes results from increased tolerance of cells to insulin resulting in a reduced effect of insulin.

Either type of Diabetes is a metabolic disorder where blood-glucose/energy levels are poorly maintained. As the endocannabinoid system is involved in maintaining energy homeostasis/balance, it has great potential in the prevention and/or treatment of Diabetes type 2. Several components of the endocannabinoid system, such as Anandamide and CB1, CB2 and GPR55 receptors, are already implicated in (the treatment of) Diabetes and more are likely to follow.

Similarly, plant cannabinoids THC and CBD have reported potential in the treatment of Diabetes and more (such as THCV) are likely to follow. Apart from regulating blood-glucose levels, the endocannabinoid system is also involved in regulating the immune system, more particularly in suppressing auto-immune responses. Therefore, in theory cannabinoids have excellent potential not just to prevent, but also to slow down or even cure both type 1 and type 2 Diabetes. More research is required to discover the true potential of cannabinoids in the treatment of Diabetes.

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