CB1

CB1 is the main Cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways. 

2AG

2AG is a major endocannabinoid produced from lipids in cellular membranes, mostly but not exclusively in response to cellular activity.

Anandamide

Anandamide was the first identified endocannabinoid, named after the Sanskrit 'ananda' for inner bliss. Anandamide is produced from lipids in cellular membranes throughout the body.

GlyR

Glycine receptors are sensitive to Glycine and produce a hyperpolarising current upon activation. GlyRs are not classic Cannabinoid receptora but their activity is modulated by cannabinoids.

Epilepsy

cannabinoids have excellent therapeutic potential in epilepsy. In the brain, cannabinoids tend to keep neuronal activity wihtin acceptable boundaries.

Pain

pain is a very good target for therapeutic cannabinoids.

Bone cancer

Bone cancers result from primary tumor invasion to bone. cannabinoids can be used to relieve Bone Cancer pain through their anti-inflammatory properties and also they could be used to treat cancer itself.

Parkinson's

Parkinson's Disease is a degenerative disorder of the nervous system marked by accelerated degeneration of dopamine-producing neurons in the Substantia Nigra in the brain.

Typical symptoms of Parkinson's Disease , such as (intentional) tremor, rigidity and slowness of movement are mostly ascribed to degenerating Substantia Nigra neurons.

Alzheimer's disease

Alzheimer’s disease is a chronic neurodegenerative disease and the main cause of dementia. Main common symptoms of dementia are related with memory but other cognitive processes are affected during the development of the disease.

Stroke

A Stroke is marked by reduced blood flow to the brain. This reduction can be due to a blocked blood vessle (ischaemia) or a ruptured blood vessle (aneurism). Either way, as a result (part of) the brain is deprived of oxygen and nutrients which in turn causes neuronal degradation and cognitive decline.