Submitted by Alberto on Tue, 05/30/2017 - 14:14
CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways.
Submitted by Alberto on Tue, 05/30/2017 - 11:35
2AG is a major
endocannabinoid produced from lipids in cellular membranes, mostly but not exclusively in response to cellular activity.
Submitted by Alberto on Tue, 05/30/2017 - 11:14
Anandamide was the first identified endocannabinoid, named after the Sanskrit 'ananda' for inner bliss. Anandamide is produced from lipids in cellular membranes throughout the body.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Schizophrenia is a chronic mental disorder that affects around 1% of the worldwide population. It causes psychotic behaviors, social and emotional disruptions and different cognitive impairments.
The causes of the disease are still not clear but studies show that both genetic and environmental factors have an effect on it.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
cannabinoids have excellent therapeutic potential for the treatment of epilepsy. In the brain, the endocannabinoid system tends to keep neuronal activity wihtin acceptable boundaries.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Posttraumatic stress disorder is considered a mental disorder caused after traumatic experiences like traffic accidents, violent circumstances, rape, warfare, etc. Typical symptoms include anxiety, nightmares, flashbacks and trauma-related cues.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
TRPV1 is part of the transient receptor potential family and is one of the non-GPCR cannabinoid receptors. TRPV1 is involved in thermoregulation and pain detection (nociception).
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
TREK-1 is a postassium channel that is constitutively leaky, thereby maintaining resting membrane potential. Mechanical membrane stretching and certain anaesthetics can open the channel, thus greatly reducing neuronal excitability.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
NMDA receptors are sensitive to the neurotransmitter glutamate. NMDArs are best known for their function in neurons as coincidence detectors and consequently their role in learning and memory. NMDArs are not classic cannabinoid receptors but their activity is modulated by cannabinoids.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Kv4.3 is a potassium channel that is involved in the repolarisation of action potentials in cardiac muscle. Kv4.3 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.
