CB1

CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways.

5HT3A

Adenosine A(2A)

Adenosine A2A Receptor is involved in neuroprotective action of CBD in Hypoxic-Isquemic injuries

TRPV2

TRPV2 is one of the non-GPCR-coupled cannabinoid receptors. TRPs are typically involved in pain sensation.

TRPV1

TRPV1 is part of the transient receptor potential family and is one of the non-GPCR cannabinoid receptors. TRPV1 is involved in thermoregulation and pain detection (nociception).

GPR55

GPR55 is a G protein-coupled receptor which binds with G protein G13. GPR55 stimulates RhoA, Cdc42 and Rac1 upon activation, suggesting a role in cell division and growth.

CB2

CB2 is primarily expressed in the immune cells and tissues of the body. Like CB1, CB2 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently lowers cAMP upon activation. This, in turn, regulates many second messenger pathways.

PPARγ

PPARγ is part of the nuclear receptor family and one of the non-GPCR cannabinoid receptors. PPARγ is involved in the regulation of fat cells/adipose tissue, insulin sensitivity and inflammation.

TRPM8

TRPM8 is involved in sensory perception.

TRPA1

TRPA1 is best known as a sensor for environmental irritants, pain, cold and stretch.