Balancing inflammation is one of the primary functions of the endocannabinoid system and research shows the involvement of several endocannabinoids and their synthesizig and degrading enzymes in the regulation of inflammation suggesting a therapeutic role for plant cannabinoids.

Crohn's disease is a chronic inflammatory bowel disease (IBD). It affects any part of the gastrointestinal tract with symptoms like abdominal pain, diarrhea, weight loss, skin rushes or fever. The causes of the disease are not well known, but genetics and environment play an important role on it.

Functional Gastro-Intestinal Disorders form a spectrum of disorders to the gastro-intestinal tract ranging from heartburn to diarrhea. Cannabis has been used for centuries to treat diseases such as diarrhea and research now shows a strong involvement of the endocannabinoid system in the function of the gastro-intestinal tract and the regulation of bowel movement.

Autism is a neurodevelopmental disorder characterized by impaired social interaction, verbal and non-verbal communication, and restricted and repetitive behavior.

Cystitis is an infection of the urinary tract.

Both plant cannabinoids and the endocannabinoid system have been implicated as risk factors in the development of depression as well as therapeutic targets to treat depression.

Diabetes has two major forms: Type 1 Diabetes is an auto-immune disorder where insulin-producing β-cells in the pancreatic Islets of Langerhans are attacked by the body's immune system resulting in reduced insulin production.

Eczema or dermatitis is a (chronic) inflammation of the skin. Eczema is marked by itchy skin and crusty skin lesions. It is not known what exactly causes Eczema but an over-active immune system may at least be part of the cause.

Huntington's disease is a genetic neurodegenerative disorder, marked by preferential degeneration of neurons in the basal ganglia (caudate and putamen) and accompanied by motor deficits, cognitive impairment and psychiatric symptoms.

Hypoxic-ischemic encephalopathy is a form of brain injury caused by oxygen deprivation during the birth process. It can cause sensorimotor and cognitive impairments including physical and intellectual disability.