2AG

2AG is a major endocannabinoid produced from lipids in cellular membranes, mostly but not exclusively in response to cellular activity.

Psychosis and Schizophrenia

Schizophrenia is a chronic mental disorder that affects around 1% of the worldwide population. It causes psychotic behaviors, social and emotional disruptions and different cognitive impairments.

The causes of the disease are still not clear but studies show that both genetic and environmental factors have an effect on it.

Epilepsy

cannabinoids have excellent therapeutic potential for the treatment of epilepsy. In the brain, the endocannabinoid system tends to keep neuronal activity wihtin acceptable boundaries.

PTSD

Posttraumatic stress disorder is considered a mental disorder caused after traumatic experiences like traffic accidents, violent circumstances, rape, warfare, etc. Typical symptoms include anxiety, nightmares, flashbacks and trauma-related cues.

TRPV1

TRPV1 is part of the transient receptor potential family and is one of the non-GPCR cannabinoid receptors. TRPV1 is involved in thermoregulation and pain detection (nociception).

TREK-1

TREK-1 is a postassium channel that is constitutively leaky, thereby maintaining resting membrane potential. Mechanical membrane stretching and certain anaesthetics can open the channel, thus greatly reducing neuronal excitability.

Cav3.1

Cav3.1 is a calcium channel of the T-type that is involved in many processes in the brain and other tissues. Contrary to other calcium channels Cav3.1 is activated by relatively low/negative voltages. Cav3.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Insomnia

Insomnia is a sleep disorder characterized by inability to sleep or sleeping less time than desired. The endocannabinoid system plays a role in sleep processes and medical cannabis users already reported benefits of cannabis use to sleep.

Pain

pain is a very good target for therapeutic cannabinoids.

Bone cancer

Bone cancers result from primary tumor invasion to bone. cannabinoids can be used to relieve bone cancer pain through their anti-inflammatory properties and also they could be used to treat cancer itself.