Psychosis and Schizophrenia

Schizophrenia is a chronic mental disorder that affects around 1% of the worldwide population. It causes psychotic behaviors, social and emotional disruptions and different cognitive impairments.

The causes of the disease are still not clear but studies show that both genetic and environmental factors have an effect on it.

Pain

pain is a very good target for therapeutic cannabinoids.

Obesity

Energy homeostasis (balance)  is one of the primary functions of the endocannabinoid system.

Diabetes

Diabetes has two major forms: Type 1 diabetes is an auto-immune disorder where insulin-producing β-cells in the pancreatic Islets of Langerhans are attacked by the body's immune system resulting in reduced insulin production. Type 2 diabetes results from increased tolerance of cells to insulin resulting in a reduced effect of insulin.

Alzheimer's disease

Alzheimer’s disease is a chronic neurodegenerative disease and the main cause of dementia. Main common symptoms of dementia are related with memory but other cognitive processes are affected during the development of the disease.

Addiction

Addiction is a complex physiological phenomenon that is intimately linked to the dopamine neurotransmitter system.

PPARγ

PPARγ is part of the nuclear receptor family and one of the non-GPCR cannabinoid receptors. PPARγ is involved in the regulation of fat cells/adipose tissue, insulin sensitivity and inflammation.

GPR18

GPR18 is involved in apoptosis, microglial migration in the CNS and other immune responses.

Migraine

Migraine is a chronic neurological disorder that is mostly characterized by severe headaches and aura.

Huntington's

Huntington's disease is a genetic neurodegenerative disorder, marked by preferential degeneration of neurons in the basal ganglia (caudate and putamen) and accompanied by motor deficits, cognitive impairment and psychiatric symptoms. There is considerable evidence for the involvement of the endocannabinoid system in Huntington's but clinical trials so far have been inconclusive.