MDMA causes hyperthermia, oxidative stress and neuronal damage while THC produces hypothermia and is anti-oxidant and anti-inflammatory. In mice that received 4 x 20 mg/kg MDMA, application of 4 x 3 mg/kg THC prevented hyperthermia, glial activation and dopaminergic terminal loss. This effect was fully CB1-dependent and partially CB2-dependent (Touriño et al., 2010).
Similarly, in rhesus monkeys, 0.3 mg/kg THC (intramuscular) prevented MDMA-induced hyperthermia (1.78 mg/kg oral) in a CB1-dependent manner (Taffe, 2012).
In rats, the after-effects of MDMA (2 x 10 mg/kg) include hyperthermia, increased anxiety-like behavior and reduced exploration. Administration of THC reduced these behavioral effects. In addition, THC normalized serotonin levels and prevented MDMA-induced neurotoxicity (Shen et al., 2011).
Shen, E.Y., Ali, S.F., and Meyer, J.S. (2011). Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats. Neuropharmacology 61, 1183–1192.
Taffe, M.A. (2012). Δ9-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys. Neuroscience 201, 125–133.
Touriño, C., Zimmer, A., and Valverde, O. (2010). THC Prevents MDMA Neurotoxicity in Mice. PLoS ONE 5.