MDMA intoxication

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Introduction

Although not exactly a disease, MDMA intoxication occurs after ingesting MDMA and typically comes with dysphoria, agitation or Insomnia.

MDMA interferes with the clearance of serotonin, dopamine and adrenalin/epinephrin from the brain, causing their levels to rise and ultimately leads to the serotonin syndrome.

As the cannabinoid system is involved in serotonergic, dopaminergic and adrenergic signalling cannabinoids have potential to counteract the serotonin syndrome.

In line with this, many recreational users of MDMA often use cannabis to soften the MDMA intoxication.

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