PEA

Suspected endocannabinoid.

Pain

pain is a very good target for therapeutic cannabinoids.

Obesity

Energy homeostasis (balance)  is one of the primary functions of the endocannabinoid system.

Alzheimer's disease

Alzheimer’s disease is a chronic neurodegenerative disease and the main cause of dementia. Main common symptoms of dementia are related with memory but other cognitive processes are affected during the development of the disease.

PPARγ

PPARγ is part of the nuclear receptor family and one of the non-GPCR cannabinoid receptors. PPARγ is involved in the regulation of fat cells/adipose tissue, insulin sensitivity and inflammation.

GPR119

GPR119 is involved in insulin secretion and its activation was shown to reduce food intake, suggesting a metabolic function.

Eczema

Eczema or dermatitis is a (chronic) inflammation of the skin. Eczema is marked by itchy skin and crusty skin lesions. It is not known what exactly causes Eczema but an over-active immune system may at least be part of the cause.

Hypoxic-ischemic encephalopathy

Hypoxic-Ischemic Encephalopathy is a form of brain injury caused by oxygen deprivation during the birth process. It can cause sensorimotor and cognitive impairments including physical and intellectual disability.

Multiple Sclerosis

Multiple Sclerosis is one of the diseases where a therapeutic role for cannabinoids has been investigated for a long time.

Bulimia

cannabinoids and endocannabinoids are known to strongly affect eating behavior. THC typically induces hunger and THCV suppresses it.