Psychosis and Schizophrenia

Schizophrenia is a chronic mental disorder that affects around 1% of the worldwide population. It causes psychotic behaviors, social and emotional disruptions and different cognitive impairments.

The causes of the disease are still not clear but studies show that both genetic and environmental factors have an effect on it.

TRPA1

TRPA1 is best known as a sensor for environmental irritants, pain, cold and stretch.

NMDAr

NMDA receptors are sensitive to the neurotransmitter glutamate. NMDArs are best known for their function in neurons as coincidence detectors and consequently their role in learning and memory. NMDArs are not classic cannabinoid receptors but their activity is modulated by cannabinoids.

Nav1.2

Nav1.2 is a sodium channel that is involved in action potential generation in neurons and in muscle. Nav1.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv4.3

Kv4.3 is a potassium channel that is involved in the repolarisation of action potentials in cardiac muscle. Kv4.3 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv3.1

Kv3.1 is a potassium channel that functions in action potential repolarisation in fast-firing neurons. Kv3.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv1.5

Kv1.5 is a potassium channel that is involved in restoring the resting membrane potential after depolarisation. Kv1.5 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv1.2

Kv1.2 is a potassium channel that is responsible for maintaining resting membrane potential and regulating excitability in neurons. Kv1.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

GPR18

GPR18 is involved in apoptosis, microglial migration in the CNS and other immune responses.

CB2

CB2 is primarily expressed in the immune cells and tissues of the body. Like CB1, CB2 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently lowers cAMP upon activation. This, in turn, regulates many second messenger pathways.