Stroke

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Introduction

A stroke is marked by reduced blood flow to the brain. This reduction can be due to a blocked blood vessle (ischaemia) or a ruptured blood vessle (aneurism). Either way, as a result (part of) the brain is deprived of oxygen and nutrients which in turn causes neuronal degradation and cognitive decline. Several cannabinoids (such as THC and CBD) and endocannabinoids (such as Anandamide and PEA) have been shown to have neuroprotective properties and thus to have therapeutic potential in the treatment of stroke. This is supported by several clinical trials showing that cannabinoid treatment after stroke significantly reduces the volume of degenerating tissue.

Alternative Names

Cerebrovascular Attack
Cerebrovascular Insult
Brain Aneurism

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Phytocannabinoids

Endocannabinoids

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Terpenes

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Prescription Advice

Clinical research suggests THC and  CBD may be beneficial in the treatment of stroke.

Given the nature of the disorder, oral or sublingual application may be beneficial.

Please follow generic prescription advice.

Please note that, while based on preclinical and/or clinical research, this prescription advice is solely intended as a guideline to help physicians determine the right prescription. We intend to continuously update our prescription advice based on patient and/or expert feedback. If you have information that this prescription advice is inaccurate, incomplete or outdated please contact us here.

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Clinical Trials

Several clinical trials have tested the therapeutic potential of cannabinoids after stroke. Meta-analysis revealed that both endocannabinoids like AEA, OEA or PEA and plant cannabinoids like THC or CBD can significantly reduce neuronal degeneration after stroke (England et al., 2015). Specifically activating CB1 and/or CB2 receptors had the strongest protective effect but other receptors such as 5-HT1A and PPARα are also likely to be involved.

Literature:

England, T.J., Hind, W.H., Rasid, N.A., and O’Sullivan, S.E. (2015). cannabinoids in experimental stroke: a systematic review and meta-analysis. J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab. 35, 348–358.