Glaucoma is a group of eye diseases that are characterized by degeneration or loss of the optic nerve, which is most likely due to increased eye (intra-ocular) pressure. Cannabis and in particular THC has long been known to lower intra-ocular pressure. Coincidentally, treatment of glaucoma is one of the oldest accepted therapeutic uses of cannabis.

Amyotrophic Lateral Sclerosis or ALS is a degenerative disease of the motor neurons that control voluntary movement. Although some genes have been linked to ALS, the majority of cases have unknown environmental causes which may lead to overexcitation or excitotoxicity of motor neurons. Early signs of ALS include muscle weakness, muscle spasms, neuropathic pain or difficulty with eating or swallowing.

Fibromyalgia is a chronic disease characterized by bone and muscle pain, multisensorial hypersensitivity, sleep disorders and tiredness. Since cannabinoids show analgesic and anti-inflammatory properties, they show potential to be used to treat fibromyalgia symptoms.

Insomnia is a sleep disorder characterized by inability to sleep or sleeping less time than desired. The endocannabinoid system plays a role in sleep processes and medical cannabis users already reported benefits of cannabis use to sleep. More research on the molecular mechanism of cannabinoids in sleep processes could uncover their potential on treating sleep disorders.

cannabinoids play an ambiguous role in anxiety: depending on the circumstances THC can either promote or suppress anxiety but CBD is anxiolytic and thus countera

Addiction is a complex physiological phenomenon that is intimately linked to the dopamine neurotransmitter system. Neurons in the dopamine system are studded with cannabinoid receptors (like CB1) which explains the addictive properties of cannabinoid substances. However, the interaction between the cannabinoid system and the dopamine system also offers opportunities for cannabinoids in the treatment of addiction to for instance alcohol, food, nicotine or opioids.

One of the best-known effects of cannabis is that it can give you the munchies. This effect can be exploited to stimulate eating in anorexia patients. Both clinical and preclinical data indicate that THC is a strong appetite stimulator. More research is required to refine appetite modulation by cannabinoids.

Autism is a neurodevelopmental disorder characterized by impaired social interaction, verbal and non-verbal communication, and restricted and repetitive behavior.

cannabinoids and endocannabinoids are known to strongly affect eating behavior. THC typically induces hunger and THCV suppresses it.

Both plant cannabinoids and the endocannabinoid system have been implicated as risk factors in the development of depression as well as therapeutic targets to treat depression.