Submitted by Alberto on Thu, 03/29/2018 - 17:22
GPR12 is an orphan receptor which has been associated with cancer metastasis, Alzheimers and Parkinson's disease. CBD acts as inverse agonist of GPR12, suggesting therapeutic potential to treat any of the mentioned diseases.
Submitted by Alberto on Tue, 08/29/2017 - 12:51
GPR6 is an orphan receptor which has been associated with Parkinson's disease. CBD acts as inverse agonist of GPR6, suggesting therapeutic potential to treat Parkinson's disease.
Submitted by Alberto on Tue, 08/29/2017 - 12:40
GPR3 is an orphan receptor which has been associated with Alzheimer's disease. CBD acts as inverse agonist of GPR3, suggesting therapeutic potential to treat Alzheimer's disease.
Submitted by Alberto on Tue, 05/30/2017 - 14:14
CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways.
Submitted by Alberto on Wed, 05/24/2017 - 17:07
Submitted by Alberto on Thu, 05/18/2017 - 18:41
The Adenosine A2A receptor is involved in the neuroprotective action of CBD in Hypoxic-Ischemic injuries
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Diabetes has two major forms: Type 1 Diabetes is an auto-immune disorder where insulin-producing β-cells in the pancreatic Islets of Langerhans are attacked by the body's immune system resulting in reduced insulin production.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Hypoxic-ischemic encephalopathy is a form of brain injury caused by oxygen deprivation during the birth process. It can cause sensorimotor and cognitive impairments including physical and intellectual disability.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Alzheimer’s disease is a chronic neurodegenerative disease and the main cause of dementia. Main common symptoms of dementia are related with memory but other cognitive processes are affected during the development of the disease.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Nav1.1 is a sodium channel that is primarily expressed in the brain and cardiac muscle where it functions in action potential generation and propagation. Nav1.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.
