TRPV4 is one of the non-GPCR-coupled cannabinoid receptors. TRPs are primarily involved in pain sensation.

TRPV3 is one of the non-GPCR-coupled cannabinoid receptors. TRPs are typically involved in pain sensation.

TRPV2 is one of the non-GPCR-coupled cannabinoid receptors. TRPs are typically involved in pain sensation.

TRPV1 is part of the transient receptor potential family and is one of the non-GPCR cannabinoid receptors. TRPV1 is involved in thermoregulation and pain detection (nociception).

α2 receptors are classically known as adrenalin receptors. However, α2 receptors also bind CBG at very high affinity and are therefore also cannabinoid receptors. The interaction between CBG and α2 receptors may be relevant in the treatment of pain and depression, but more research is required.

δ-opioid receptors are primarily sensitive to opioids and enkephalins. δ-opioid receptors are not classic cannabinoid receptors but their activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on δ-opioid receptors they are effectively cannabinoid receptors.

TRPM8 is involved in sensory perception.

TRPA1 is best known as a sensor for environmental irritants, pain, cold and stretch.

TREK-1 is a postassium channel that is constitutively leaky, thereby maintaining resting membrane potential. Mechanical membrane stretching and certain anaesthetics can open the channel, thus greatly reducing neuronal excitability.

pparγ is part of the nuclear receptor family and one of the non-GPCR cannabinoid receptors. pparγ is involved in the regulation of fat cells/adipose tissue, insulin sensitivity and inflammation.