GPR6

GPR6 is an orphan receptor which has been associated with Parkinson's disease. CBD acts as inverse agonist of GPR6, suggesting therapeutic potential to treat Parkinson's disease.

GPR3

GPR3 is an orphan receptor which has been associated with Alzheimer's disease. CBD acts as inverse agonist of GPR3, suggesting therapeutic potential to treat Alzheimer's disease.

CB1

CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways.

5-HT3A

A2A (Adenosine)

The Adenosine A2A receptor is involved in the neuroprotective action of CBD in Hypoxic-Ischemic injuries

5-HT1A

5-HT1A is a serotonin receptor. 5-HT1A is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on 5-HT1A it is effectively a cannabinoid receptor.

Hypoxic-ischemic encephalopathy

Hypoxic-ischemic encephalopathy is a form of brain injury caused by oxygen deprivation during the birth process. It can cause sensorimotor and cognitive impairments including physical and intellectual disability. The endocannabinoid system can regulate the underlying processes of hypoxic-ischemic encephalopathy when its occurring, therefore cannabinoids could help to ameliorate the symptoms related to it.

Diabetes

Diabetes has two major forms: Type 1 diabetes is an auto-immune disorder where insulin-producing β-cells in the pancreatic Islets of Langerhans are attacked by the body's immune system resulting in reduced insulin production. Type 2 diabetes results from increased tolerance of cells to insulin resulting in a reduced effect of insulin.

Alzheimer's disease

Alzheimer’s disease is a chronic neurodegenerative disease and the main cause of dementia. Main common symptoms of dementia are related with memory but other cognitive processes are affected during the development of the disease. cannabinoids have great potential in the prevention and treatment of the pathogenesis and symptomatology of Alzheimer’s disease.

Nav1.5

Nav1.5 is a sodium channel that is primarily found in cardiac muscle where it is responsible for action potential generation/cardiac muscle contraction. Nav1.5 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.