5-HT2A

5-HT2A is a serotonin receptor. 5-HT2A is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Cav3.3

Cav3.3 is a calcium channel of the T-type that is involved in many brain processes. Contrary to other calcium channels Cav3.3 is activated by relatively low/negative voltages.

5-HT1A

5-HT1A is a serotonin receptor. 5-HT1A is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

nAChR

Nicotinic acetylcholine receptors/nAChRs are involved in cognitive processes in the brain and in controlling muscle movement. nAChRs are not classic cannabinoid receptors but their activity is modulated by cannabinoids.

5-HT3

5-HT3 is a serotonin receptor. 5-HT3 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

GPCR introduction

G Protein Coupled Receptors (GPCRs) are a large family of transmembrane receptors that control a vast array of cellular processes. GPCRs are bound to G Proteins which can be monomeric (single subunit) or heterotrimeric and made up of α, β and γ subunits. Gα subunits can be roughly divided into three functional groups: