Functional Gastro-Intestinal Disorders form a spectrum of disorders to the gastro-intestinal tract ranging from heartburn to diarrhea. Cannabis has been used for centuries to treat diseases such as diarrhea and research now shows a strong involvement of the endocannabinoid system in the function of the gastro-intestinal tract and the regulation of bowel movement.

One of the best-known effects of cannabis is that it can give you the munchies. This effect can be exploited to stimulate eating in anorexia patients. Both clinical and preclinical data indicate that THC is a strong appetite stimulator. More research is required to refine appetite modulation by cannabinoids.

cannabinoids and endocannabinoids are known to strongly affect eating behavior. THC typically induces hunger and THCV suppresses it.

Diabetes has two major forms: Type 1 Diabetes is an auto-immune disorder where insulin-producing β-cells in the pancreatic Islets of Langerhans are attacked by the body's immune system resulting in reduced insulin production.

Energy homeostasis (balance)  is one of the primary functions of the endocannabinoid system.