Diabetes has two major forms: Type 1 Diabetes is an auto-immune disorder where insulin-producing β-cells in the pancreatic Islets of Langerhans are attacked by the body's immune system resulting in reduced insulin production.

Eczema or dermatitis is a (chronic) inflammation of the skin. Eczema is marked by itchy skin and crusty skin lesions. It is not known what exactly causes Eczema but an over-active immune system may at least be part of the cause.

Although not exactly a disease, MDMA intoxication occurs after ingesting MDMA and typically comes with dysphoria, agitation or insomnia.

MDMA interferes with the clearance of serotonin, dopamine and adrenalin/epinephrin from the brain, causing their levels to rise and ultimately leads to the serotonin syndrome.

Migraine is a chronic neurological disorder that is mostly characterized by severe headaches and aura.

Morphine is an opioid drug used to treat acute and chronic pain.

Tourette's Syndrome is a neuropsychiatric disorder that is marked by a collection of motor- and vocal tics. Tourette's is inherited and is believed to result from dysfunctional cortical and subcortical regions in the brain.

The Acquired Immune Deficiency Syndrome is caused by the Human Immunodeficiency Virus. HIV/AIDS attacks cells of the immune system making the body more susceptible to infections and tumors. As a result, patients often suffer from nausea, loss of appetite, intractable pain and other secondary symptoms often associated with cancer (cachexia/wasting syndrome).

COPD is a chronic lung disease. To date, no cure exists for COPD and therefore most treatments focus on reducing symptoms and suppressing discomfort.

Multiple Sclerosis is one of the diseases where a therapeutic role for cannabinoids has been investigated for a long time.

Energy homeostasis (balance)  is one of the primary functions of the endocannabinoid system.