Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
schizophrenia is a chronic mental disorder that affects around 1% of the worldwide population. It causes psychotic behaviors, social and emotional disruptions and different cognitive impairments.
The causes of the disease are still not clear but studies show that both genetic and environmental factors have an effect on it.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
TRPV1 is part of the transient receptor potential family and is one of the non-GPCR cannabinoid receptors. TRPV1 is involved in thermoregulation and pain detection (nociception).
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
TREK-1 is a postassium channel that is constitutively leaky, thereby maintaining resting membrane potential. Mechanical membrane stretching and certain anaesthetics can open the channel, thus greatly reducing neuronal excitability.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Cav3.1 is a calcium channel of the T-type that is involved in many processes in the brain and other tissues. Contrary to other calcium channels Cav3.1 is activated by relatively low/negative voltages. Cav3.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Cav3.1 it is effectively a cannabinoid receptor.
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
Submitted by heiko@ghsctradi... on Mon, 03/14/2016 - 13:14
