Caryophyllene was found to be therapeutic in the following diseases:

• Alcoholism (Al Mansouri et al., 2014)
• Analgesic (Fiorenzani et al., 2014)(Klauke et al., 2014)
• Anti-bacterial, anti-fungal (Selestino Neta et al., 2017)
• Anti-convulsant (de Oliveira et al., 2016)
• Anti-genotoxic/anti-oxidant (Alvarez-González et al., 2014)
• Anti-inflammatory in alcoholic steatohepatitis (Varga et al., 2017)
• Anti-inflammatory in Diabetes model (Basha and Sankaranarayanan, 2014, 2016)
• Anti-inflammatory, anti-catabolic, pro-anabolic in osteoarthritis model (Rufino et al., 2015)
• Anti-lymphoma, anti-neuroblastoma (Sain et al., 2014)
• Anti-mutagenic (Di Giacomo et al., 2016)
• Anti-neuroinflammatory in Alzheimer’s model (Hu et al., 2017)(Cheng et al., 2014)
• Anti-neuroinflammatory in hypoxia stroke model (Guo et al., 2014)
• Anti-neuroinflammatory in Parkinson’s model (Ojha et al., 2016)
• Anti-neutrophil chemotaxis (Andrade-Silva et al., 2016)
• Anti-nociceptive (de Oliveira Júnior et al., 2017)(Katsuyama et al., 2013)
• Anxiolytic (Galdino et al., 2012)(Bahi et al., 2014)
• Atherosclerosis  (Zhang et al., 2017b)(Baldissera et al., 2017c)
• cancer and analgesic (Fidyt et al., 2016)
• Cerebral ischemia (Choi et al., 2013)(Chang et al., 2013)(Lou et al., 2016)(Zhang et al., 2017a)(Tian et al., 2016)
• Chemosensitization to doxorubicin in cancer cell lines (DI Giacomo et al., 2017)(Ambrož et al., 2017)(Hanušová et al., 2017)(Ambrož et al., 2015)
• Colorectal cancer and anti-bacterial (Dahham et al., 2015)
• Endometriosis (Abbas et al., 2013)
• Immunosuppressive in hypercholesterolemia (Baldissera et al., 2017a, 2017a, 2017b)
• Increased liver fatty acid uptake and oxidation (Wu et al., 2014)
• Insulin regulation (Suijun et al., 2014)
• Liver fibrosis (Calleja et al., 2013)
• Longevity in C. elegans (Pant et al., 2014)
• Melanoma (Jung et al., 2015)
• Mosquito larvicidal (Govindarajan et al., 2016)
• Motor paralysis and neuroinflammation in MS model (Alberti et al., 2017)(Fontes et al., 2017)
• Neuritogenesis in PC12 cells (Santos et al., 2017)
• Neuroinflammation in Parkinson’s model (Javed et al., 2016)
• Neuroprotective in seizures (Liu et al., 2015)
• Non Alcoholic Fatty Liver Disease (Kamikubo et al., 2016)
• Osteoporosis (Shan et al., 2017)(Yamaguchi and Levy, 2016)
• Oviposition deterrent for Aedes aegypti (da Silva et al., 2015)
• Vascular dementia (Lou et al., 2017)

References:

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Tian, X., Peng, J., Zhong, J., Yang, M., Pang, J., Lou, J., Li, M., An, R., Zhang, Q., Xu, L., et al. (2016). β-Caryophyllene protects in vitro neurovascular unit against oxygen-glucose deprivation and re-oxygenation-induced injury. J. Neurochem. 139, 757–768.

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Zhang, Q., An, R., Tian, X., Yang, M., Li, M., Lou, J., Xu, L., and Dong, Z. (2017a). β-Caryophyllene Pretreatment Alleviates Focal Cerebral Ischemia-Reperfusion Injury by Activating PI3K/Akt Signaling Pathway. Neurochem. Res. 42, 1459–1469.

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