CB1

CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways.

OCD

OCD is an Anxiety disorder characterised by the obsessive urge for repetitive behaviour.

Psoriasis

Psoriasis is an auto-immune disease characterized by itchy skin lesions. Psoriasis arises when the immune system mistakenly identifies skin cells as foreign matter and causes over-production of new skin cells.

Pain

Pain is a very good target for therapeutic cannabinoids. Many endocannabinoids, plant cannabinoids and cannabinoid receptors have been linked to pain management or analgesia.

Huntington's

Huntington's disease is a genetic neurodegenerative disorder, marked by preferential degeneration of neurons in the basal ganglia (caudate and putamen) and accompanied by motor deficits, cognitive impairment and psychiatric symptoms. There is considerable evidence for the involvement of the endocannabinoid system in Huntington's but clinical trials so far have been inconclusive.

Epilepsy

cannabinoids have excellent therapeutic potential in epilepsy. In the brain, cannabinoids tend to keep neuronal activity wihtin acceptable boundaries. More importantly, cannabinoids prevent hypersynchronisation of cortical neurons (which is the very definition of a seizure).

Depression

Both plant cannabinoids and the endocannabinoid system have been implicated as risk factors in the development of depression as well as therapeutic targets to treat depression.

COPD

COPD is a chronic lung disease. To date, no cure exists for COPD and therefore most treatments focus on reducing symptoms and suppressing discomfort. cannabinoids have properties such as boosting the immune system and clearing away compromised cells which could help cure COPD.

TRPM8

TRPM8 is involved in sensory perception.

α2r

α2 receptors are classically known as adrenalin receptors. However, α2 receptors also bind CBG at very high affinity and are therefore also cannabinoid receptors. The interaction between CBG and α2 receptors may be relevant in the treatment of pain and depression, but more research is required.