Addiction is a complex physiological phenomenon that is intimately linked to the dopamine neurotransmitter system. Neurons in the dopamine system are studded with cannabinoid receptors (like CB1) which explains the addictive properties of cannabinoid substances. However, the interaction between the cannabinoid system and the dopamine system also offers opportunities for cannabinoids in the treatment of addiction to for instance alcohol, food, nicotine or opioids.