Receptors

CBC activates TRPA1 channels and alters the expression of the mRNA encoding for TRPV1, TRPV2, TRPV3 and TRPV4. These receptors are involved in gastrointestinal inflammation (De Petrocellis et al., 2012; De Petrocellis et al., 2008, 2011)

CBC inhibits Anandamide uptale (De Petrocellis et al., 2011)

Acne

CBC shows anti-acne effects (Oláh et al., 2016)

Gastrointestinal Inflammation

The anti-inflammatory properties of CBC ameliorates gastrointestinal inflammation like colitis in animal models through the activation of TRPA1 receptor (Romano et al., 2013)

CBC also reduces hypermotility associated to gastrointestinal inflammation (Izzo et al., 2012)

CBC shows anti-inflammatory effects in the lipopolysacchariede paw edema assay. These effects are increased when CBC is combined with THC (DeLong, Wolf, Poklis, & Lichtman, 2010)

pain

CBC can regulate nociceptive control and produce analgesia through TRP receptors (Maione et al., 2011)

depression

CBC (20 mg/kg) displayed significant anti-depressant activity. The anti-depressant effects of the different cannabinoids display different dose-dependency and are probably reached through different receptors. s (El-Alfy et al., 2010)

References:

De Petrocellis, L., Ligresti, A., Moriello, A. S., Allarà, M., Bisogno, T., Petrosino, S., … Di Marzo, V. (2011). Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. British Journal of Pharmacology, 163(7), 1479-1494. https://doi.org/10.1111/j.1476-5381.2010.01166.x

De Petrocellis, L., Orlando, P., Moriello, A. S., Aviello, G., Stott, C., Izzo, A. A., & Di Marzo, V. (2012). cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation. Acta Physiologica (Oxford, England), 204(2), 255-266. https://doi.org/10.1111/j.1748-1716.2011.02338.x

De Petrocellis, L., Vellani, V., Schiano-Moriello, A., Marini, P., Magherini, P. C., Orlando, P., & Di Marzo, V. (2008). Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8. The Journal of Pharmacology and Experimental Therapeutics, 325(3), 1007-1015. https://doi.org/10.1124/jpet.107.134809

DeLong, G. T., Wolf, C. E., Poklis, A., & Lichtman, A. H. (2010). Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ(9)-tetrahydrocannabinol. Drug and Alcohol Dependence, 112(1-2), 126-133. https://doi.org/10.1016/j.drugalcdep.2010.05.019

El-Alfy, A. T., Ivey, K., Robinson, K., Ahmed, S., Radwan, M., Slade, D., … Ross, S. (2010). Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacology, Biochemistry, and Behavior, 95(4), 434-442. https://doi.org/10.1016/j.pbb.2010.03.004

Izzo, A. A., Capasso, R., Aviello, G., Borrelli, F., Romano, B., Piscitelli, F., … Di Marzo, V. (2012). Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. British Journal of Pharmacology, 166(4), 1444-1460. https://doi.org/10.1111/j.1476-5381.2012.01879.x

Maione, S., Piscitelli, F., Gatta, L., Vita, D., De Petrocellis, L., Palazzo, E., … Di Marzo, V. (2011). Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action. British Journal of Pharmacology, 162(3), 584-596. https://doi.org/10.1111/j.1476-5381.2010.01063.x

Oláh, A., Markovics, A., Szabó-Papp, J., Szabó, P. T., Stott, C., Zouboulis, C. C., & Bíró, T. (2016). Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment. Experimental Dermatology, 25(9), 701-707. https://doi.org/10.1111/exd.13042

Romano, B., Borrelli, F., Fasolino, I., Capasso, R., Piscitelli, F., Cascio, M., … Izzo, A. (2013). The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis. British Journal of Pharmacology, 169(1), 213-229. https://doi.org/10.1111/bph.12120