K-ATP is a potassium channel that is sensitive to ATP and therefore to cellular energy levels. K-ATP functions to control cellular energy levels. K-ATP is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on K-ATP it is effectively a cannabinoid receptor.
K-ATP is present on both plasma- and intracellular membranes.
Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.
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