Cav3.1 is a calcium channel of the T-type that is involved in many processes in the brain and other tissues. Contrary to other calcium channels Cav3.1 is activated by relatively low/negative voltages. Cav3.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Cav3.1 it is effectively a cannabinoid receptor.
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=535
http://en.wikipedia.org/wiki/CACNA1G
NarGly nada Anandamide CBD Δ9THC
References:
Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.
Brain > ovary > placenta. Cerebellum > thalamus > neocortex > substantia nigra > medulla > striatum.
For an interactive version, please visit https://www.proteinatlas.org
